(153) Levorphanol, another choice in opioid rotation
نویسندگان
چکیده
منابع مشابه
Levorphanol: An Optimal Choice for Opioid Rotation
Levorphanol, termed “the forgotten opioid,” is a potent opioid analgesic available for the treatment of moderate to severe pain. It was first approved in 1953, and it has a wide range of ascending and descending pain pathway receptor-mediated pharmacological activities, including mu, delta, and kappa (kappa 1 and 3) opioid agonism; N-methyl-D-aspartate (NMDA) antagonism; and reuptake inhibition...
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Mice were made tolerant to a large dose of levorphanol, a congener of morphine. Then (3)H-levorphanol was given. The concentration of free, unchanged levorphanol in the brain water (ultrafiltrate) was found to be much higher than required to produce pharmacologic effects in nontolerant animals. The result indicates that tolerance arises from a diminished sensitivity to the drug at cellular or s...
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There are no two people in pain management that I can think of who have saved more lives than Drs. Webster and Fine. In their piece suggesting a new paradigm for opioid rotation [1], they add a distinctly useful clinical approach to what heretofore has been their empirical, political, and advisory efforts in this domain. Dr. Webster has worked tirelessly with his Lifetree foundation and with th...
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Patients requiring chronic opioid therapy may not respond to or tolerate the first opioid prescribed to them, necessitating rotation to another opioid. They may also require dose increases for a number of reasons, including worsening disease and increased pain. Dose escalation to restore analgesia using the primary opioid may lead to increased adverse events. In these patients, rotation to a di...
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ژورنال
عنوان ژورنال: The Journal of Pain
سال: 2016
ISSN: 1526-5900
DOI: 10.1016/j.jpain.2016.01.056